You may be aware that Pfizer Company’s
ZOETIS division is deeply into Genomics and has been researching
“wellness” traits with the assistance of associate dairy herds (all the way
from Michigan to Florida) that have generated reams of data on cows that have
all been DNA-mapped.
Dr Dan Weigel (working from Zoetis
Labs in Kalamazoo, MI) heads up this effort, which has special significance for
us (Dan is the breeder of 99HO7070 Jehosophat at International
Protein Sires). He made a
presentation to explain DWP$ and its supporting Genomic traits at
the recent IPS Distributor conference in Wisconsin. Their Genomic service is named Clarifide
Plus.
Zoetis offers the
following evaluations: Mastitis (32%
culling risk), Lameness (16% culling risk), Metritis (17% culling risk),
Retained Placenta (31% culling risk), Displaced Abomasum (27% culling risk),
Ketosis (32% culling risk). Their
research indicates costs of $117 to $494 per incidence for treatment of
these various dairy herd afflictions. Thus
Zoetis assigns dollar values to the genomic possession of markers for
resistance to these various issues.
This adds up eventually to the DWP$ once added to or
subtracted from CDCB’s “Net Merit” genetic index values.
For the individual genomic traits,
breed average is expressed as 100. A
sire with superior DNA markers will have a trait score above 100; a sire lacking
those markers will have a trait score below 100. Across the Holstein population, these scores
range from a low of 69 to a high of 116 (the individual traits have individual
ranges). The Reliability % of these
traits is currently from 49% to 51%.
Examples of enhanced sire data
incorporating “Wellness Traits” (International Protein Sires)
Progeny evaluated sires:
566H 1199 Cambridge Mast 108
Lame 104 Met 103 RP 104 Ket 106 DA 102
DWP$ 532
compare this to his calculated Net
Merit of $299, and we find him to be an exceptional bull!
099H 7070 Jehosophat
Mast 95 Lame 101 Met 107 RP 101
Ket 108 DA 105 DWP$ 493
compare this to his calculated net
Merit of $399, provides added value in five of six wellness traits.
006H 1157 Made Right
Mast 106 Lame 99
Met 101 RP 96
Ket 99 DA 103 DWP$ 490
low SCS of 2.86, high PL of +4.6,
now with LIV +1.7, low stillbirth 6.7%, clearly a “health” bull
566H 0588 Gilby Mast 97
Lame 100 Met 110 RP
104 Ket 110
DA 99 DWP$ 486
exceeds his calculated Net Merit of
$381, and in the top percentiles for Metritis and Ketosis resistance
566H 1247 Galt Mast 101 Lame 101 Met 101 RP 95
Ket 105 DA
103 DWP$ 458
compare this to his calculated Net
Merit of $341, and we find him to be a significantly better bull.
566H 1180 Rollag Mast 102 Lame
95 Met 103 RP 107 Ket
105 DA 101 DWP$ 429
compare this to his calculated Net
Merit of $330, and we find him to be a significantly better bull.
Genomic estimated sires:
566H 1265 Jenner Mast 101 Lame 112 Met 111
RP 104 Ket 111 DA 106
DWP$ 1075
in the top five of all sires tested
for “wellness traits”—compare to Net Merit of $778, a true outlier!
566H 1261 Jo Dandy Mast
98 Lame 101 Met 103 RP 108 Ket
96 DA 106 DWP$ 1020
might he be the highest DWP$ choice
for those also seeking the consumer-health A2A2 Beta casein?
566H 1267 Fix It Mast 111 Lame
90 Met 104 RP
95 Ket 98
DA 107 DWP$ 1015
starting from an elite $801 NM,
still a good boost to a sire whose +2.42 G Type draws attention.
566H 1260 Storm Proof
Mast 105 Lame 100 Met 100
RP 106 Ket 100 DA 106
DWP$ 993
a significant bump from Net Merit
$790, and pretty good for an elite +2680 GTPI cow family sire
Genomic estimated sires: (continued)
566H 1262 Diverse Mast 105 Lame 105 Met 102 RP
99 Ket 95
DA 102 DWP$ 970
who says four generations of “EX”
dams with outstanding mature records cannot transmit something?
566H 1237 Milton Mast 106 Lame 100 Met 104 RP 102 Ket 104
DA 103 DWP$ 948
Michigan-bred from Powell’s best
cow family, compare to Net Merit of $751-- realize hidden value.
566H 1263 Malcolm Mast 100
Lame 101 Met 103 RP 100
Ket 106 DA 103 DWP$
927
all this health with exceptional
+.17% +86 fat and +.08% +55 protein and low 2.79 SCS ($779 NM)
566H 1244 Ethics Mast 103 Lame 100
Met 101 RP 96
Ket 106 DA 104 DWP$
915
compare to estimated Net Merit of
$785, shows he has extra value in metabolic and udder health
566H 1251 Net Worth Mast 101 Lame 101
Met 105 RP 93
Ket 111 DA 105
DWP$ 888
gets five out of six right from a Michigan-bred cow line that shows
consistency every generation
Some observations on interpretation
You will note that the range of IPS’ best Genomic sires is twice the $
value of IPS’ better progeny evaluated sires.
This is simply because DWP$ is a recalculation of Net Merit
enhanced by Zoetis’ added insights into the genotype for those health
characteristics that are major cost issues for dairy.
Higher-ranking Genomic sires are assumed to be a “generation ahead” of
the better progeny data evaluated sires.
Thus it is best to remember that Genomic traits top out at 75%
Reliability while the verification of milking and classified progeny is still
needed to reach the most reliable 95%-99% level.
How does “Clarified Plus” compare to the patented AI stud health
indicators?
Being the first to go public with any new technology is usually to
offer an incomplete solution to the perceived problem. “Immunity Plus” for example neither grades
bulls on the relative levels of their
gene possession nor covers as much trait territory as does the Zoetis
“Clarifide Plus” technology.
I expect you will observe that the
major AI systems will all gravitate toward Clarifide Plus rather than
attempt to develop their own, more limited versions. Pfizer’s great resources dwarf those
available to any individual AI system, and anything related to interpretation
of the Genotype demands resources in computing power usually only available to
government or university research collaborations. Mostly, Zoetis’ novel approach to ranking
the economic values imputed to avoiding these various cow problems helps us
sort among bulls where it soon becomes apparent that there is no “perfect”
bull—you have to make some decisions that prioritize the traits most
important to your herd at this generation of cows.
The biggest disadvantage to any
single-stud proprietary system is that it compares against that stud’s average, NOT
the attained breed average. We
have already seen the disparity from sampling to 99% distribution on type
proofs, for example—bulls who begin at +2.00 and end up –1.50 once they face
the rest of their contemporaries, not just the “in house” populations held
captive by full-service contracts.
The Zoetis data comes from
herds that offer a full cross-section of the competing genetic AI programs and
involves millions of fully documented health episodes, and is an ongoing
research today.
At no extra cost
At this point it appears we will eventually have
Clarifide Plus “wellness” data on Genomic tested sires from all our major sire
sources. Currently, this technology is
limited to Holsteins. (Zoetis does make
this technology available on farm for testing your cows and heifers, should you
wish to pre-select which heifers you raise for replacements (allowing early
sale of those surplus to your needs).)